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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620436
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cga
Name: glycoprotein hormones, alpha polypeptide
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDEstradiol results in decreased expression of CGA mRNA

PMID:16522720, PMID:16614383, PMID:21187122
multiple interactionsEXP 6480464CTDEstradiol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CGA mRNA]

PMID:21187122
increases abundanceISORGD:13485906480464CTDCGA protein results in increased abundance of Estradiol

PMID:19501113, PMID:20378682
increases expressionISORGD:13485906480464CTDEstradiol results in increased expression of CGA protein

PMID:19580841
multiple interactionsISORGD:13485906480464CTD[CGA protein co-treated with FSHB protein] affects the abundance of Estradiol, fulvestrant inhibits the reaction [Estradiol results in increased expression of CGA protein], mono-(2-ethylhexyl)phthalate inhibits the reaction [CGA protein results in increased abundance of Estradiol]

PMID:19501113, PMID:19580841, PMID:22451503
multiple interactionsISORGD:7318386480464CTDESR2 gene mutant form inhibits the reaction [CGA protein results in increased abundance of Estradiol]

PMID:20378682
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.