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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620432
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Myog
Name: myogenin
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Myogaffects methylationISOMYOG (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of MYOG promoterPMID:27901495
Myogdecreases expressionISOMYOG (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of MYOG proteinPMID:24431215
Myogdecreases expressionISOMyog (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of MYOG mRNA; Benzo(a)pyrene results in decreased expression of MYOG proteinPMID:35427736
Myogdecreases methylationISOMYOG (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of MYOG exonPMID:27901495
Myogincreases mutagenesisISOMYOG (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of MYOG genePMID:25435355
Myogmultiple interactionsISOMYOG (Homo sapiens)6480464CTDalpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of MYOG protein]; Fulvestrant inhibits the reaction [Benzo(a)pyrene results in decreased expression of MYOG protein]PMID:24431215
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