GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620410
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ltb4r
Name: leukotriene B4 receptor
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:15501236480464CTDTetrachlorodibenzodioxin results in decreased expression of LTB4R1 mRNA

PMID:24680724
increases expressionISORGD:15501236480464CTDTetrachlorodibenzodioxin results in increased expression of LTB4R1 mRNA

PMID:28487374
multiple interactionsISORGD:13480206480464CTD[Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of LTB4R mRNA

PMID:14761676
multiple interactionsISORGD:15501236480464CTDLTB4R1 mRNA promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]

LTB4R1 mRNA promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA]

PMID:28487374
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.