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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:76359
Term: butylated hydroxyanisole
Definition: A mixture of 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole. Is is used as an antioxidant and preservative in food, cosmetics, pharmaceuticals, rubber and petroleum products.
Chemical ID: MESH:D002083
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2increases expressionEXP 6480464CTDButylated Hydroxyanisole results in increased expression of NFE2L2 proteinPMID:23027624
Nfe2l2multiple interactionsEXP 6480464CTDButylated Hydroxyanisole inhibits the reaction [Estradiol inhibits the reaction [NFE2L2 protein binds to SOD3 promoter]]PMID:23027624
Nfe2l2affects activityISONfe2l2 (Mus musculus)6480464CTDButylated Hydroxyanisole affects the activity of NFE2L2 proteinPMID:11309284
Nfe2l2affects response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 protein affects the susceptibility to Butylated HydroxyanisolePMID:30844440
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDButylated Hydroxyanisole results in increased stability of and results in increased expression of NFE2L2 proteinPMID:22530035
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD[Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNA; [Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC3 mRNA; [Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC4 mRNA; [Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC5 mRNA; [Butylated Hydroxyanisole results in increased activity of NFE2L2 protein] which results in increased expression of ABCC6 mRNA; Butylated Hydroxyanisole binds to and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole affects the reaction [Dextran Sulfate affects the expression of IL6 protein]]; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole affects the reaction [Dextran Sulfate affects the expression of TNF protein]]; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]]; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole results in increased activity of GSTM1 protein]; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole results in increased activity of GSTP1 protein]; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole results in increased expression of GSTP1 protein]PMID:11895860 PMID:15833929 PMID:15919853 PMID:30844440
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