Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:6925
Term: microcystin-LR
Definition: A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins.
Chemical ID: MESH:C057862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects expressionISONFE2L2 (Homo sapiens)6480464CTDcyanoginosin LR affects the expression of NFE2L2 proteinPMID:20600217
Nfe2l2affects response to substanceISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 protein affects the susceptibility to cyanoginosin LRPMID:20722399
Nfe2l2decreases degradationISONFE2L2 (Homo sapiens)6480464CTDcyanoginosin LR results in decreased degradation of NFE2L2 proteinPMID:20722399
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD[cyanoginosin LR affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 mRNA; [cyanoginosin LR affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; cyanoginosin LR inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of NFE2L2 protein]; cyanoginosin LR promotes the reaction [sulforaphane affects the localization of NFE2L2 protein]; cyanoginosin LR results in increased expression of and results in increased activity of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the susceptibility to [cyanoginosin LR results in increased expression of HMOX1 protein]; NFE2L2 protein affects the susceptibility to [cyanoginosin LR results in increased expression of NQO1 protein]PMID:20600217 PMID:20722399
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD[Thioctic Acid co-treated with cyanoginosin LR] results in increased expression of NFE2L2 proteinPMID:32061150
Go Back to source page   Continue to Ontology report