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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects localizationEXP 6480464CTDMethamphetamine affects the localization of NFE2L2 proteinPMID:19564919
Nfe2l2increases expressionEXP 6480464CTDMethamphetamine results in increased expression of NFE2L2 mRNAPMID:19564919 PMID:30450033
Nfe2l2multiple interactionsEXP 6480464CTDLactulose promotes the reaction [Methamphetamine results in increased expression of NFE2L2 mRNA]; SCH 23390 inhibits the reaction [Methamphetamine affects the localization of NFE2L2 protein]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of NFE2L2 mRNA]PMID:19564919 PMID:30450033
Nfe2l2affects response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 protein affects the susceptibility to MethamphetaminePMID:37567421
Nfe2l2increases expressionISONfe2l2 (Mus musculus)6480464CTDMethamphetamine results in increased expression of NFE2L2 proteinPMID:37567421
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDNFE2L2 protein affects the reaction [Methamphetamine results in increased expression of BECN1 protein]; NFE2L2 protein affects the reaction [Methamphetamine results in increased expression of HAVCR1 protein]; NFE2L2 protein affects the reaction [Methamphetamine results in increased expression of MAP1LC3B protein]; sulforaphane promotes the reaction [Methamphetamine results in increased expression of NFE2L2 protein]PMID:37567421
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