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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects activityEXP 6480464CTDMetformin affects the activity of NFE2L2 proteinPMID:25596134
Nfe2l2decreases expressionEXP 6480464CTDMetformin results in decreased expression of NFE2L2 mRNA; Metformin results in decreased expression of NFE2L2 proteinPMID:22627169 PMID:25596134
Nfe2l2multiple interactionsEXP 6480464CTDMetformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]PMID:33639173 PMID:36999408
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDMetformin results in decreased expression of NFE2L2 mRNA; Metformin results in decreased expression of NFE2L2 proteinPMID:23707609 PMID:33838154
Nfe2l2increases activityISONfe2l2 (Mus musculus)6480464CTDMetformin results in increased activity of NFE2L2 proteinPMID:30114225
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDMetformin inhibits the reaction [2-tert-butylhydroquinone results in increased stability of and affects the localization of NFE2L2 protein]; Metformin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L2 protein]PMID:23707609 PMID:33838154
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDMetformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NFE2L2 protein]PMID:37120126
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