GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | increases expression | EXP | | 6480464 | CTD | Ketoconazole results in increased expression of NFE2L2 mRNA; Ketoconazole results in increased expression of NFE2L2 protein | PMID:31168027 PMID:37077353 | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | [Ketoconazole co-treated with Carbon Tetrachloride] results in increased expression of NFE2L2 protein | PMID:31168027 | Nfe2l2 | increases expression | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Ketoconazole results in increased expression of NFE2L2 mRNA; Ketoconazole results in increased expression of NFE2L2 protein | PMID:21753779 | Nfe2l2 | multiple interactions | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | [Ketoconazole results in increased activity of AHR protein] which results in increased activity of and results in increased localization of NFE2L2 protein; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]] | PMID:21753779 | | ||||||||||||||||||||||
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