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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:34055
Term: 1,2-naphthoquinone
Definition: The parent structure of the family of 1,2-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 2 of the naphthalene ring. It is a metabolite of naphthalene and is found in diesel exhaust particles.
Chemical ID: MESH:C040756
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects response to substanceISONfe2l2 (Mus musculus)6480464CTD[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to 1,2-naphthoquinone; NFE2L2 protein affects the susceptibility to 1,2-naphthoquinonePMID:19303893 PMID:21384861
Nfe2l2increases activityISONfe2l2 (Mus musculus)6480464CTD1,2-naphthoquinone results in increased activity of NFE2L2 proteinPMID:21384861 PMID:21651925 PMID:25807370
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTD1,2-naphthoquinone results in increased expression of NFE2L2 mRNAPMID:26862668
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDNFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to 1,2-naphthoquinone]PMID:20932822
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