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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:27086
Term: tributylstannane
Definition: An organotin compound that has formula C12H28Sn.
Chemical ID: MESH:C011559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2increases expressionEXP 6480464CTDtributyltin results in increased expression of NFE2L2 proteinPMID:24055800 PMID:26079211 PMID:28707438
Nfe2l2multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [tributyltin results in increased expression of NFE2L2 protein]; Phycocyanin inhibits the reaction [tributyltin results in increased expression of NFE2L2 protein]PMID:26079211
Nfe2l2increases localizationISONfe2l2 (Mus musculus)6480464CTDtributyltin results in increased localization of NFE2L2 proteinPMID:36858641
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDPRKCD gene mutant form promotes the reaction [tributyltin affects the localization of and results in increased activity of NFE2L2 protein]PMID:25895139
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