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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:17963
Term: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Definition: A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.
Chemical ID: MESH:D015632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2decreases expressionISONfe2l2 (Mus musculus)6480464CTD1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NFE2L2 mRNA; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NFE2L2 proteinPMID:24991814 PMID:29071302 PMID:31187328 PMID:33368846 PMID:34967706 PMID:38016618
Nfe2l2increases response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 gene mutant form results in increased susceptibility to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridinePMID:22746536
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NFE2L2 protein]; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NFE2L2 protein]; Levodopa inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects the expression of MIR380 mRNA]; NFE2L2 protein affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MIR138-1 mRNA]; NFE2L2 protein affects the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MIR674 mRNA]; salvianolic acid B inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NFE2L2 protein]PMID:24991814 PMID:29071302 PMID:33368846 PMID:38016618
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