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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:17230
Term: homocysteine
Definition: A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.
Chemical ID: MESH:D006710
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects localizationISONFE2L2 (Homo sapiens)6480464CTDHomocysteine affects the localization of NFE2L2 protein modified formPMID:22964297
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDHomocysteine results in increased expression of NFE2L2 mRNAPMID:22964297
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein]; Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 proteinPMID:22964297
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDacetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Homocysteine results in decreased expression of NFE2L2 protein]; Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein; L 709049 inhibits the reaction [Homocysteine results in decreased expression of NFE2L2 protein]; N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal inhibits the reaction [Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein]PMID:22964297
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