GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | increases expression | EXP | | 6480464 | CTD | Berberine results in increased expression of NFE2L2 protein | PMID:23523906 | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | Berberine inhibits the reaction [Bortezomib results in increased expression of NFE2L2 mRNA]; Berberine promotes the reaction [Bleomycin results in increased expression of NFE2L2 protein] | PMID:23523906 PMID:35121005 | Nfe2l2 | increases activity | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Berberine results in increased activity of NFE2L2 protein | PMID:30818834 | Nfe2l2 | increases expression | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Berberine results in increased expression of NFE2L2 protein | PMID:23954465 | Nfe2l2 | multiple interactions | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | NFE2L2 mutant form inhibits the reaction [Berberine inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein] | PMID:23954465 | Nfe2l2 | multiple interactions | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Berberine inhibits the reaction [Particulate Matter results in decreased expression of NFE2L2 protein] | PMID:37839514 | |
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