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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:16118
Term: berberine
Definition: A botanical anti-fungal agent that has formula C20H18NO4.
Chemical ID: MESH:D001599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2increases expressionEXP 6480464CTDBerberine results in increased expression of NFE2L2 proteinPMID:23523906
Nfe2l2multiple interactionsEXP 6480464CTDBerberine inhibits the reaction [Bortezomib results in increased expression of NFE2L2 mRNA]; Berberine promotes the reaction [Bleomycin results in increased expression of NFE2L2 protein]PMID:23523906 PMID:35121005
Nfe2l2increases activityISONFE2L2 (Homo sapiens)6480464CTDBerberine results in increased activity of NFE2L2 proteinPMID:30818834
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDBerberine results in increased expression of NFE2L2 proteinPMID:23954465
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 mutant form inhibits the reaction [Berberine inhibits the reaction [Glucose results in increased abundance of Reactive Oxygen Species]]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [Berberine results in increased expression of NGF protein]PMID:23954465
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDBerberine inhibits the reaction [Particulate Matter results in decreased expression of NFE2L2 protein]PMID:37839514
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