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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:28077
Term: rifampicin
Definition: A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei).
Chemical ID: MESH:D012293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2decreases expressionEXP 6480464CTDRifampin results in decreased expression of NFE2L2 mRNA; Rifampin results in decreased expression of NFE2L2 proteinPMID:33307820
Nfe2l2multiple interactionsEXP 6480464CTD[tanshinone co-treated with Rifampin] results in increased expression of NFE2L2 mRNA; tanshinone inhibits the reaction [Rifampin results in decreased expression of NFE2L2 mRNA]; tanshinone inhibits the reaction [Rifampin results in decreased expression of NFE2L2 protein]PMID:33307820
Nfe2l2decreases activityISONfe2l2 (Mus musculus)6480464CTDRifampin results in decreased activity of NFE2L2 proteinPMID:33412187
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDRifampin results in increased expression of NFE2L2 proteinPMID:31678598
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDRifampin inhibits the reaction [arsenite results in increased activity of NFE2L2 protein]PMID:33412187
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