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GENE - TERM ANNOTATION REPORT

RGD ID: 620351
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3a
Name: glycogen synthase kinase 3 alpha
Acc ID: GO:0090090
Term: negative regulation of canonical Wnt signaling pathway
Definition: Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
Definition Source(s): GOC:dph, GOC:tb
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3ainvolved_inIBAFB:FBgn0003371 or MGI:1861437 or PANTHER:PTN001173193 or UniProtKB:P49841 or WB:WBGene000017461600115GO_CentralGO_REF:0000033

GO_REF:0000033
Gsk3ainvolved_inIEAPANTHER:PTHR24057:SF141600115TreeGrafterGO_REF:0000118

GO_REF:0000118
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