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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620331
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pafah1b1
Name: platelet-activating factor acetylhydrolase 1b, regulatory subunit 1
Acc ID: CHEBI:3048
Term: benzatropine
Definition: Tropane in which a hydrogen at position 3 is substituted by a diphenylmethoxy group (endo-isomer). An acetylcholine receptor antagonist, it is used (particularly as its methanesulphonate salt) in the treatment of Parkinson's disease, and to reduce parkinsonism and akathisia side effects of antipsychotic treatments.
Chemical ID: MESH:D001590
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pafah1b1multiple interactionsISOPAFAH1B1 (Homo sapiens)6480464CTD[Cuprizone co-treated with Benztropine] results in decreased expression of PAFAH1B1 proteinPMID:34122009
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