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GENE - TERM ANNOTATION REPORT

RGD ID: 620317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Phyh
Name: phytanoyl-CoA 2-hydroxylase
Acc ID: GO:0001561
Term: fatty acid alpha-oxidation
Definition: A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.
Definition Source(s): PMID:10198260
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Phyh IDA 727286RGD  
Phyhacts_upstream_of_or_withinISOPhyh (Mus musculus)1624291RGD PMID:12915479 PMID:9326939

PMID:12915479 PMID:9326939
Phyhinvolved_inISOPHYH (Homo sapiens)1624291RGD PMID:16186124 PMID:9326939

PMID:16186124 PMID:9326939
Phyhinvolved_inIBAMGI:891978 or PANTHER:PTN001084068 or Phyh (Rattus norvegicus) or UniProtKB:O148321600115GO_CentralGO_REF:0000033

GO_REF:0000033
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