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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620314
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ryr2
Name: ryanodine receptor 2
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ryr2increases expressionEXP 6480464CTDNicotine results in increased expression of RYR2 mRNA; Nicotine results in increased expression of RYR2 proteinPMID:21113126
Ryr2multiple interactionsEXP 6480464CTDCREB1 protein promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]; Nicotine promotes the reaction [CREB1 protein modified form binds to RYR2 promoter]PMID:21113126
Ryr2increases expressionISORyr2 (Mus musculus)6480464CTDNicotine results in increased expression of RYR2 mRNAPMID:21113126
Ryr2multiple interactionsISORyr2 (Mus musculus)6480464CTDCHRNB2 promotes the reaction [Nicotine results in increased expression of RYR2 mRNA]PMID:21113126
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