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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620311
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr7a2
Name: aldo-keto reductase family 7, member A2
Acc ID: CHEBI:32585
Term: 4-hydroxynon-2-enal
Definition: An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.
Chemical ID: MESH:C027576
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr7a2affects response to substanceISOAKR7A2 (Homo sapiens)6480464CTDAKR7A2 protein affects the susceptibility to 4-hydroxy-2-nonenalPMID:30849339
Akr7a2decreases response to substanceISOAKR7A2 (Homo sapiens)6480464CTDAKR7A2 protein results in decreased susceptibility to 4-hydroxy-2-nonenalPMID:22001351
Akr7a2increases expressionISOAKR7A2 (Homo sapiens)6480464CTD4-hydroxy-2-nonenal results in increased expression of AKR7A2 mRNA; 4-hydroxy-2-nonenal results in increased expression of AKR7A2 proteinPMID:22964423 PMID:30849339
Akr7a2increases response to substanceISOAKR7A2 (Homo sapiens)6480464CTDAKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenalPMID:22964423
Akr7a2multiple interactionsISOAKR7A2 (Homo sapiens)6480464CTD7-hydroxycoumarin affects the reaction [AKR7A2 mutant form results in increased susceptibility to 4-hydroxy-2-nonenal]; AKR7A2 protein affects the reaction [NFE2L2 protein affects the susceptibility to 4-hydroxy-2-nonenal]PMID:22964423 PMID:30849339
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