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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62030
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Myh7
Name: myosin heavy chain 7
Acc ID: CHEBI:9948
Term: verapamil
Definition: A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
Chemical ID: MESH:D014700
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Myh7decreases expressionISOMyh7 (Mus musculus)6480464CTDVerapamil results in decreased expression of MYH7 mRNAPMID:19596060
Myh7multiple interactionsISOMyh7 (Mus musculus)6480464CTDDexamethasone inhibits the reaction [Verapamil results in decreased expression of MYH7 mRNA]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Verapamil results in decreased expression of MYH7 mRNA]]PMID:19596060
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