GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ereg | affects expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of EREG mRNA | PMID:22298810 | Ereg | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | PMID:20558275 PMID:21215274 PMID:21724226 PMID:24046277 PMID:33387578 | Ereg | multiple interactions | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to EREG promoter] | PMID:16192470 | Ereg | affects expression | ISO | EREG (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of EREG mRNA | PMID:22298810 | Ereg | affects expression | ISO | Ereg (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of EREG mRNA | PMID:16962184 PMID:26377647 | Ereg | increases expression | ISO | EREG (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | PMID:16704738 PMID:20064835 PMID:20106945 PMID:23152189 PMID:23625689 PMID:26159488 PMID:27913140 | Ereg | increases expression | ISO | Ereg (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of EREG mRNA | PMID:16192470 PMID:16929009 PMID:18691609 PMID:19770486 PMID:19933214 PMID:25270620 | Ereg | increases secretion | ISO | EREG (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased secretion of EREG protein | PMID:23625689 PMID:27117977 | Ereg | multiple interactions | ISO | EREG (Homo sapiens) | 6480464 | CTD | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with IL1B protein] results in increased expression of EREG mRNA]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of EREG mRNA]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of EREG protein]; [AREG protein co-treated with EREG protein co-treated with TGFA protein] affects the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK1 protein]; [AREG protein co-treated with EREG protein co-treated with TGFA protein] affects the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK3 protein]; [Tetrachlorodibenzodioxin co-treated with IL1B protein] results in increased expression of EREG mRNA; batimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of EREG protein]; EREG mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] | PMID:23625689 PMID:27117977 | Ereg | multiple interactions | ISO | Ereg (Mus musculus) | 6480464 | CTD | [Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of EREG mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of EREG mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to EREG promoter] | PMID:16192470 PMID:25975270 | |
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