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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620299
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ereg
Name: epiregulin
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eregaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of EREG mRNAPMID:22298810
Eregincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of EREG mRNAPMID:20558275 PMID:21215274 PMID:21724226 PMID:24046277 PMID:33387578
Eregmultiple interactionsEXP 6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to EREG promoter]PMID:16192470
Eregaffects expressionISOEREG (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of EREG mRNAPMID:22298810
Eregaffects expressionISOEreg (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of EREG mRNAPMID:16962184 PMID:26377647
Eregincreases expressionISOEREG (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of EREG mRNAPMID:16704738 PMID:20064835 PMID:20106945 PMID:23152189 PMID:23625689 PMID:26159488 PMID:27913140
Eregincreases expressionISOEreg (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of EREG mRNAPMID:16192470 PMID:16929009 PMID:18691609 PMID:19770486 PMID:19933214 PMID:25270620
Eregincreases secretionISOEREG (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased secretion of EREG proteinPMID:23625689 PMID:27117977
Eregmultiple interactionsISOEREG (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with IL1B protein] results in increased expression of EREG mRNA]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of EREG mRNA]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of EREG protein]; [AREG protein co-treated with EREG protein co-treated with TGFA protein] affects the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK1 protein]; [AREG protein co-treated with EREG protein co-treated with TGFA protein] affects the reaction [Tetrachlorodibenzodioxin results in increased activity of MAPK3 protein]; [Tetrachlorodibenzodioxin co-treated with IL1B protein] results in increased expression of EREG mRNA; batimastat inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of EREG protein]; EREG mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]PMID:23625689 PMID:27117977
Eregmultiple interactionsISOEreg (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of EREG mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of EREG mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to EREG promoter]PMID:16192470 PMID:25975270
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