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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620289
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Trim28
Name: tripartite motif-containing 28
Acc ID: CHEBI:75249
Term: potassium chromate
Definition: A potassium salt consisting of potassium and chromate ions in a 2:1 ratio.
Chemical ID: MESH:C027373
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7362656480464CTDpotassium chromate(VI) results in increased expression of TRIM28 protein modified form

PMID:25977998
multiple interactionsISORGD:7362656480464CTD2-(2, 6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [potassium chromate(VI) results in increased expression of TRIM28 protein modified form], 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [potassium chromate(VI) results in increased expression of TRIM28 protein modified form], Ascorbic Acid inhibits the reaction [potassium chromate(VI) results in increased expression of TRIM28 protein modified form], ATM protein promotes the reaction [potassium chromate(VI) results in increased expression of TRIM28 protein modified form], CHEK2 protein promotes the reaction [potassium chromate(VI) results in increased expression of TRIM28 protein modified form]

PMID:25977998
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.