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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620288
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Calr
Name: calreticulin
Acc ID: CHEBI:64215
Term: 2,3-dimethoxynaphthalene-1,4-dione
Definition: A naphthoquinone that is 1,4-naphthoquinone bearing two methoxy substituents at positions 2 and 3. Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. Used to study the role of ROS in cell toxicity, apoptosis, and necrosis.
Chemical ID: MESH:C063002
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Calrdecreases expressionISOCALR (Homo sapiens)6480464CTD2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of CALR mRNAPMID:17547211
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