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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620265
Species: Rattus norvegicus
RGD Object: Gene
Symbol: S100a8
Name: S100 calcium binding protein A8
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
S100a8increases expressionISOS100A8 (Homo sapiens)6480464CTDGlucose results in increased expression of S100A8 mRNA; Glucose results in increased expression of S100A8 proteinPMID:19833897
S100a8multiple interactionsISOS100A8 (Homo sapiens)6480464CTDGLO1 inhibits the reaction [Glucose promotes the reaction [JUN protein binds to S100A8 promoter]]; GLO1 inhibits the reaction [Glucose results in increased expression of S100A8 mRNA]; GLO1 inhibits the reaction [Glucose results in increased expression of S100A8 protein]; Glucose promotes the reaction [JUN protein binds to S100A8 promoter]; JUN promotes the reaction [Glucose results in increased expression of S100A8 mRNA]; SOD2 inhibits the reaction [Glucose results in increased expression of S100A8 mRNA]; SOD2 inhibits the reaction [Glucose results in increased expression of S100A8 protein]; UCP1 inhibits the reaction [Glucose results in increased expression of S100A8 mRNA]; UCP1 inhibits the reaction [Glucose results in increased expression of S100A8 protein]PMID:19833897
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