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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620196
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp13
Name: matrix metallopeptidase 13
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp13decreases expressionISOMmp13 (Mus musculus)6480464CTDDexamethasone results in decreased expression of MMP13 mRNAPMID:19997594
Mmp13multiple interactionsISOMMP13 (Homo sapiens)6480464CTD[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA; IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA]PMID:26526931
Mmp13multiple interactionsISOMmp13 (Mus musculus)6480464CTD[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA; NR3C1 protein promotes the reaction [Dexamethasone results in decreased expression of MMP13 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]PMID:19997594 PMID:23503329
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