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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620190
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Becn1
Name: beclin 1
Acc ID: CHEBI:5262
Term: galangin
Definition: A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells.
Chemical ID: MESH:C037032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Becn1increases expressionISOBECN1 (Homo sapiens)6480464CTDgalangin results in increased expression of BECN1 mRNA; galangin results in increased expression of BECN1 proteinPMID:25268046
Becn1multiple interactionsISOBECN1 (Homo sapiens)6480464CTD[BECN1 mutant form co-treated with galangin] results in decreased activity of CASP3 protein; LY2109761 inhibits the reaction [galangin results in increased expression of BECN1 protein]; SMAD4 mutant form inhibits the reaction [galangin results in increased expression of BECN1 protein]PMID:25268046
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