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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620180
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc40a1
Name: solute carrier family 40 member 1
Acc ID: CHEBI:30052
Term: copper(0)
Definition: An elemental copper that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCopper deficiency results in decreased expression of SLC40A1 protein

PMID:18505688
increases expressionEXP 6480464CTDCopper deficiency results in increased expression of SLC40A1 mRNA, Copper deficiency results in increased expression of SLC40A1 protein

PMID:20164366, PMID:21355016
affects expressionISORGD:7330736480464CTDCopper affects the expression of SLC40A1 mRNA, Copper affects the expression of SLC40A1 protein

PMID:16614410
decreases expressionISORGD:7330726480464CTDCopper deficiency results in decreased expression of SLC40A1 mRNA

PMID:18505688
increases expressionISORGD:7330726480464CTDCopper results in increased expression of SLC40A1 protein

PMID:12220667
increases expressionISORGD:7330736480464CTDCopper deficiency results in increased expression of SLC40A1 mRNA, Copper deficiency results in increased expression of SLC40A1 protein, Copper results in increased expression of SLC40A1 mRNA, Copper results in increased expression of SLC40A1 protein

PMID:20016736, PMID:23555700
multiple interactionsISORGD:7330736480464CTDEPAS1 gene mutant form inhibits the reaction [Copper deficiency results in increased expression of SLC40A1 mRNA]

PMID:23555700
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.