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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620180
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc40a1
Name: solute carrier family 40 member 1
Acc ID: CHEBI:29035
Term: manganese(2+)
Definition: A divalent metal cation in which the metal is manganese.
Chemical ID: MESH:D008345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7330736480464CTDManganese results in decreased expression of SLC40A1 mRNA

PMID:29020610
increases exportISORGD:7330726480464CTDSLC40A1 protein results in increased export of Manganese

PMID:22178646
multiple interactionsISORGD:7330726480464CTDCobalt inhibits the reaction [SLC40A1 protein results in increased export of Manganese], Iron inhibits the reaction [SLC40A1 protein results in increased export of Manganese], Nickel inhibits the reaction [SLC40A1 protein results in increased export of Manganese]

PMID:22178646
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.