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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620175
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgf21
Name: fibroblast growth factor 21
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgf21multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of FGF21 mRNA; [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of FGF21 mRNA; [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF21 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of FGF21 mRNA]PMID:18164116 PMID:22129741
Fgf21multiple interactionsISOFgf21 (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of FGF21 mRNAPMID:24535843
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