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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620175
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fgf21
Name: fibroblast growth factor 21
Acc ID: CHEBI:15354
Term: choline
Definition: A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function.
Chemical ID: MESH:D002794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fgf21multiple interactionsISOFgf21 (Mus musculus)6480464CTD[Choline deficiency co-treated with Folic Acid deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 mRNA; [Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 mRNA; [Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 protein; [Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in decreased expression of FGF21 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FGF21 mRNA; [Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FGF21 mRNA; Methionine inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 mRNA]; Methionine inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 protein]; NFE2L2 affects the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of FGF21 mRNA]PMID:20350562 PMID:20938992 PMID:25178843 PMID:28163111 PMID:29127188
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