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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620161
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp26a1
Name: cytochrome P450, family 26, subfamily a, polypeptide 1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp26a1affects expressionISOCyp26a1 (Mus musculus)6480464CTDProgesterone affects the expression of CYP26A1 mRNAPMID:17251523
Cyp26a1increases expressionISOCYP26A1 (Homo sapiens)6480464CTDProgesterone results in increased expression of CYP26A1 mRNAPMID:17404688
Cyp26a1multiple interactionsISOCYP26A1 (Homo sapiens)6480464CTD[Estradiol co-treated with Progesterone] results in increased expression of CYP26A1 mRNA; [Progesterone co-treated with Estradiol] results in increased expression of CYP26A1 mRNAPMID:17404688 PMID:20660070
Cyp26a1multiple interactionsISOCyp26a1 (Mus musculus)6480464CTD[Progesterone results in increased activity of PGR protein] which results in increased expression of CYP26A1 mRNAPMID:15845616
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