GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bid | increases expression | EXP | | 6480464 | CTD | Doxorubicin results in increased expression of BID protein | PMID:24902966 | Bid | increases phosphorylation | EXP | | 6480464 | CTD | Doxorubicin results in increased phosphorylation of BID protein | PMID:18845810 | Bid | multiple interactions | EXP | | 6480464 | CTD | HMOX1 protein inhibits the reaction [Doxorubicin results in increased phosphorylation of BID protein]; Quercetin inhibits the reaction [Doxorubicin results in increased expression of BID protein] | PMID:18845810 PMID:24902966 | Bid | affects cleavage | ISO | BID (Homo sapiens) | 6480464 | CTD | Doxorubicin affects the cleavage of BID protein | PMID:15870702 | Bid | decreases expression | ISO | BID (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of BID mRNA | PMID:16705698 PMID:29803840 | Bid | increases expression | ISO | Bid (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased expression of BID mRNA | PMID:26873546 | Bid | increases response to substance | ISO | BID (Homo sapiens) | 6480464 | CTD | BID protein results in increased susceptibility to Doxorubicin | PMID:15289866 | Bid | multiple interactions | ISO | BID (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein]; [Doxorubicin co-treated with Phellinus linteus extract] results in increased cleavage of BID protein; [Indomethacin results in increased cleavage of BID protein] which results in increased susceptibility to Doxorubicin; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein]]; BCL2 protein inhibits the reaction [PI103 promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein]]; BCL2L1 protein inhibits the reaction [BID protein results in increased susceptibility to Doxorubicin]; Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein; PI103 promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein] | PMID:15289866 PMID:15812552 PMID:16868541 PMID:20856197 | Bid | multiple interactions | ISO | Bid (Mus musculus) | 6480464 | CTD | [Doxorubicin co-treated with Dexrazoxane] results in decreased expression of BID mRNA | PMID:26873546 | | ||||||||||||||||||||||
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