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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620103
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bad
Name: BCL2-associated agonist of cell death
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baddecreases phosphorylationISOBad (Mus musculus)6480464CTDDexamethasone results in decreased phosphorylation of BAD proteinPMID:16644695
Badincreases expressionISOBad (Mus musculus)6480464CTDDexamethasone results in increased expression of BAD mRNAPMID:16644695
Badincreases phosphorylationISOBad (Mus musculus)6480464CTDDexamethasone results in increased phosphorylation of BAD proteinPMID:30878453
Badmultiple interactionsISOBad (Mus musculus)6480464CTDMifepristone inhibits the reaction [Dexamethasone results in decreased phosphorylation of BAD protein]; Mifepristone inhibits the reaction [Dexamethasone results in increased expression of BAD mRNA]; MK 2206 inhibits the reaction [Dexamethasone results in increased phosphorylation of BAD protein]; naringin inhibits the reaction [Dexamethasone results in increased phosphorylation of BAD protein]PMID:16644695 PMID:30878453
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