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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620103
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bad
Name: BCL2-associated agonist of cell death
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baddecreases response to substanceISOBAD (Homo sapiens)6480464CTDBAD protein modified form results in decreased susceptibility to Cisplatin; BAD results in decreased susceptibility to CisplatinPMID:21849418
Badincreases expressionISOBad (Mus musculus)6480464CTDCisplatin results in increased expression of BAD proteinPMID:35304134
Badincreases expressionISOBAD (Homo sapiens)6480464CTDCisplatin results in increased expression of BAD mRNAPMID:20878077
Badmultiple interactionsISOBad (Mus musculus)6480464CTDRutin inhibits the reaction [Cisplatin results in increased expression of BAD protein]PMID:35304134
Badmultiple interactionsISOBAD (Homo sapiens)6480464CTD[PPM1A results in decreased phosphorylation of BAD protein] which results in increased susceptibility to Cisplatin; [PRKACA results in increased phosphorylation of BAD protein] which results in decreased susceptibility to Cisplatin; Cisplatin promotes the reaction [Metformin results in increased expression of BAD protein]; Y 27632 inhibits the reaction [Cisplatin results in increased expression of BAD mRNA]PMID:20878077 PMID:21388661 PMID:21849418
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