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GENE - TERM ANNOTATION REPORT

RGD ID: 620093
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xylt1
Name: xylosyltransferase 1
Acc ID: GO:0015012
Term: heparan sulfate proteoglycan biosynthetic process
Definition: The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Definition Source(s): GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xylt1involved_inISOXYLT1 (Homo sapiens)1624291RGD PMID:17189265

PMID:17189265
Xylt1involved_inIBAFB:FBgn0015360 or PANTHER:PTN005271747 or UniProtKB:Q86Y38 or UniProtKB:Q9H1B51600115GO_CentralGO_REF:0000033

GO_REF:0000033
Xylt1involved_inIEAUniPathway:UPA007561600115UniProtGO_REF:0000041

GO_REF:0000041
Xylt1involved_inISSUniProtKB:Q86Y381600115UniProtGO_REF:0000024

GO_REF:0000024
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