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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620089
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ocln
Name: occludin
Acc ID: CHEBI:81520
Term: 2,3',4,4',5-Pentachlorobiphenyl
Definition: A pentachlorobiphenyl that has formula C12H5Cl5.
Chemical ID: MESH:C070055
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Oclndecreases expressionEXP 6480464CTD2,3',4,4',5-pentachlorobiphenyl results in decreased expression of OCLN proteinPMID:20299304
Oclndecreases expressionISOOCLN (Homo sapiens)6480464CTD2,3',4,4',5-pentachlorobiphenyl results in decreased expression of OCLN proteinPMID:20299304
Oclnmultiple interactionsISOOcln (Mus musculus)6480464CTD2,3',4,4',5-pentachlorobiphenyl affects the reaction [TJP1 protein binds to OCLN protein]PMID:20064788
Oclnmultiple interactionsISOOCLN (Homo sapiens)6480464CTD[2,3',4,4',5-pentachlorobiphenyl co-treated with Lipopolysaccharides] results in decreased expression of OCLN protein; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [[2,3',4,4',5-pentachlorobiphenyl co-treated with Lipopolysaccharides] results in decreased expression of OCLN protein]; IRF3 mutant form inhibits the reaction [[2,3',4,4',5-pentachlorobiphenyl co-treated with Lipopolysaccharides] results in decreased expression of OCLN protein]PMID:22906770
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