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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620089
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ocln
Name: occludin
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of OCLN protein

PMID:15618353
multiple interactionsEXP 6480464CTDN(6), N(6)-dimethyladenine promotes the reaction [Cadmium Chloride results in decreased expression of OCLN protein]

PMID:15618353
decreases expressionISORGD:16240786480464CTDCadmium Chloride results in decreased expression of OCLN protein

PMID:26424772
increases expressionISORGD:7329856480464CTDCadmium Chloride results in increased expression of OCLN mRNA

PMID:25851441
increases phosphorylationISORGD:7329856480464CTDCadmium Chloride results in increased phosphorylation of OCLN protein

PMID:25851441
multiple interactionsISORGD:16240786480464CTDflavocoxid inhibits the reaction [Cadmium Chloride results in decreased expression of OCLN protein]

PMID:26424772
multiple interactionsISORGD:7329856480464CTDbisindolylmaleimide I inhibits the reaction [Cadmium Chloride affects the localization of OCLN protein], bisindolylmaleimide I inhibits the reaction [Cadmium Chloride results in increased phosphorylation of OCLN protein], Cadmium Chloride affects the localization of and results in decreased expression of OCLN protein

PMID:25851441
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.