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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620059
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc31a1
Name: solute carrier family 31 member 1
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc31a1increases expressionEXP 6480464CTDCopper deficiency results in increased expression of SLC31A1 mRNA; Copper deficiency results in increased expression of SLC31A1 protein; Copper results in increased expression of SLC31A1 mRNA; Copper results in increased expression of SLC31A1 proteinPMID:15591161 PMID:21781943 PMID:22362149
Slc31a1increases importEXP 6480464CTDSLC31A1 protein results in increased import of CopperPMID:23123662
Slc31a1increases secretionEXP 6480464CTDSLC31A1 protein results in increased secretion of CopperPMID:16741141
Slc31a1increases transportEXP 6480464CTDSLC31A1 protein results in increased transport of CopperPMID:22465424
Slc31a1increases uptakeEXP 6480464CTDSLC31A1 protein results in increased uptake of CopperPMID:24316150
Slc31a1multiple interactionsEXP 6480464CTDCopper inhibits the reaction [SLC31A1 protein results in increased import of oxaliplatin]; Fructose inhibits the reaction [Copper deficiency results in increased expression of SLC31A1 protein]; lead acetate promotes the reaction [SLC31A1 protein results in increased uptake of Copper]; PRL protein promotes the reaction [SLC31A1 protein results in increased secretion of Copper]; Silver inhibits the reaction [SLC31A1 protein results in increased import of Copper]; SLC31A1 mutant form inhibits the reaction [Lead results in decreased export of Copper]; Zinc inhibits the reaction [SLC31A1 protein results in increased import of Copper]PMID:16741141 PMID:21781943 PMID:23123662 PMID:24316150
Slc31a1affects abundanceISOSlc31a1 (Mus musculus)6480464CTDSLC31A1 gene mutant form affects the abundance of CopperPMID:12177073
Slc31a1affects localizationISOSLC31A1 (Homo sapiens)6480464CTDCopper affects the localization of SLC31A1 proteinPMID:12501239 PMID:23543413 PMID:24967972
Slc31a1affects transportISOSlc31a1 (Mus musculus)6480464CTDSLC31A1 protein affects the transport of CopperPMID:17268249
Slc31a1affects uptakeISOSLC31A1 (Homo sapiens)6480464CTDSLC31A1 protein affects the uptake of CopperPMID:12872841
Slc31a1decreases abundanceISOSlc31a1 (Mus musculus)6480464CTDSLC31A1 protein modified form results in decreased abundance of CopperPMID:24167251
Slc31a1decreases expressionISOSLC31A1 (Homo sapiens)6480464CTDCopper results in decreased expression of SLC31A1 mRNA; Copper results in decreased expression of SLC31A1 proteinPMID:18483225 PMID:19685012 PMID:26067577
Slc31a1decreases response to substanceISOSLC31A1 (Homo sapiens)6480464CTDSLC31A1 protein mutant form results in decreased susceptibility to CopperPMID:20519567
Slc31a1decreases transportISOSLC31A1 (Homo sapiens)6480464CTDSLC31A1 protein mutant form results in decreased transport of CopperPMID:20519567
Slc31a1decreases uptakeISOSLC31A1 (Homo sapiens)6480464CTDSLC31A1 mutant form results in decreased uptake of CopperPMID:23543413
Slc31a1increases abundanceISOSlc31a1 (Mus musculus)6480464CTDSLC31A1 protein results in increased abundance of CopperPMID:24522273
Slc31a1increases degradationISOSLC31A1 (Homo sapiens)6480464CTDCopper results in increased degradation of SLC31A1 proteinPMID:12501239 PMID:17108132
Slc31a1increases expressionISOSLC31A1 (Homo sapiens)6480464CTDCopper deficiency results in increased expression of SLC31A1 mRNA; Copper deficiency results in increased expression of SLC31A1 protein; Copper results in increased expression of SLC31A1 proteinPMID:18483225 PMID:18779306 PMID:24708542
Slc31a1increases importISOSLC31A1 (Homo sapiens)6480464CTDSLC31A1 protein results in increased import of CopperPMID:23426973 PMID:23658018 PMID:24132751 PMID:25091475 PMID:25320179
Slc31a1increases transportISOSLC31A1 (Homo sapiens)6480464CTDSLC31A1 protein results in increased transport of CopperPMID:12220667 PMID:16982196 PMID:19570948
Slc31a1increases uptakeISOSLC31A1 (Homo sapiens)6480464CTDSLC31A1 protein mutant form results in increased uptake of Copper; SLC31A1 protein results in increased uptake of CopperPMID:12177073 PMID:12501239 PMID:14976198 PMID:15634647 PMID:17525160 PMID:17627945 PMID:18779306 PMID:22569840 PMID:22914438 PMID:23543413
Slc31a1increases uptakeISOSlc31a1 (Mus musculus)6480464CTDSLC31A1 protein results in increased uptake of CopperPMID:11391004 PMID:12177073 PMID:16847145 PMID:19095764 PMID:19509135
Slc31a1multiple interactionsISOSLC31A1 (Homo sapiens)6480464CTD[bathocuproine sulfonate results in decreased abundance of Copper] which results in increased expression of SLC31A1 mRNA; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [SLC31A1 protein results in increased import of Copper]; [CLDN3 protein results in increased expression of SLC31A1 protein] which results in increased import of and results in increased abundance of Copper; [CLDN4 protein results in increased expression of SLC31A1 protein] which results in increased import of and results in increased abundance of Copper; [Copper results in decreased expression of SLC31A1 mRNA] which results in decreased uptake of Copper; [ITGAV protein results in decreased expression of SLC31A1 protein] which results in decreased abundance of Copper; [Metribolone results in increased expression of SLC31A1 protein] which results in increased import of Copper; [NSC 689534 binds to Copper] which results in increased expression of SLC31A1 mRNA; [SLC11A2 protein co-treated with SLC31A1 protein] affects the uptake of Copper; Buthionine Sulfoximine inhibits the reaction [SLC31A1 protein results in increased import of Copper]; Chlorpromazine inhibits the reaction [Copper affects the localization of SLC31A1 protein]; Cisplatin inhibits the reaction [SLC31A1 protein results in increased import of Copper]; Copper deficiency promotes the reaction [SP1 protein results in increased expression of SLC31A1 mRNA]; Copper inhibits the reaction [SP1 protein results in increased expression of SLC31A1 mRNA]; Copper results in decreased expression of and affects the localization of SLC31A1 protein; Copper results in increased degradation of and affects the localization of SLC31A1 protein; Estradiol inhibits the reaction [Copper results in decreased expression of SLC31A1 protein]; Estradiol promotes the reaction [Copper affects the expression of SLC31A1 mRNA]; glutathione diethyl ester inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [SLC31A1 protein results in increased import of Copper]]; methyl-beta-cyclodextrin inhibits the reaction [Copper affects the localization of SLC31A1 protein]; SLC31A1 protein results in increased susceptibility to [cupric chloride results in increased abundance of Copper]PMID:12501239 PMID:14976198 PMID:18483225 PMID:19685012 PMID:20971185 PMID:22172574 PMID:23053666 PMID:23426973 PMID:24132751 PMID:24485600 PMID:25320179 PMID:25594011 PMID:26067577 PMID:32278528
Slc31a1multiple interactionsISOSlc31a1 (Mus musculus)6480464CTD[ATP7B gene mutant form results in decreased export of Copper] which results in decreased expression of SLC31A1 protein; [ATP7B gene mutant form results in increased uptake of Copper] which results in decreased expression of SLC31A1 protein; [Oxygen deficiency results in increased expression of SLC31A1 protein] which results in increased uptake of Copper; [SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of SOD1 protein; [SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of TYR protein; [SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased expression of COX1 protein; [SLC31A1 gene mutant form results in increased abundance of CCS protein] which results in decreased abundance of Copper; [SLC31A2 protein results in increased expression of SLC31A1 protein modified form] which results in decreased abundance of Copper; Copper inhibits the reaction [[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of SOD1 protein]; Copper inhibits the reaction [[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of TYR protein]; Copper inhibits the reaction [[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased expression of COX1 protein]; SLC31A1 protein results in increased uptake of and results in increased abundance of Copper; SLC31A2 protein inhibits the reaction [SLC31A1 protein results in increased uptake of and results in increased abundance of Copper]PMID:12177073 PMID:19351718 PMID:20647314 PMID:22802922 PMID:22842628 PMID:24167251
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