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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Polg
Name: DNA polymerase gamma, catalytic subunit
Acc ID: CHEBI:38940
Term: sunitinib
Definition: A pyrrole that has formula C22H27FN4O2.
Chemical ID: MESH:C473478
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Polgaffects response to substanceISOPOLG (Homo sapiens)6480464CTDPOLG affects the susceptibility to sunitinibPMID:26385865
Polgdecreases expressionISOPOLG (Homo sapiens)6480464CTDsunitinib results in decreased expression of POLG mRNA; sunitinib results in decreased expression of POLG proteinPMID:26385865
Polgincreases expressionISOPOLG (Homo sapiens)6480464CTDSunitinib results in increased expression of POLG mRNAPMID:31533062
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