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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620047
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il2
Name: interleukin 2
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il2decreases expressionEXP 6480464CTDCyclophosphamide results in decreased expression of IL2 proteinPMID:18848347
Il2increases expressionEXP 6480464CTDCyclophosphamide results in increased expression of IL2 mRNAPMID:11948286
Il2decreases expressionISOIl2 (Mus musculus)6480464CTDCyclophosphamide results in decreased expression of IL2 mRNAPMID:32151603
Il2decreases secretionISOIl2 (Mus musculus)6480464CTDCyclophosphamide results in decreased secretion of IL2 proteinPMID:23395935
Il2increases expressionISOIl2 (Mus musculus)6480464CTDCyclophosphamide results in increased expression of IL2 mRNAPMID:11006010
Il2multiple interactionsISOIl2 (Mus musculus)6480464CTD(4-formyl-9-methoxy-5-methyl-naphtho(2,3-b)furan-3-yl)methyl acetate inhibits the reaction [Cyclophosphamide results in decreased secretion of IL2 protein]; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of IL2 mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased expression of IL2 mRNA]; Levamisole inhibits the reaction [Cyclophosphamide results in decreased secretion of IL2 protein]PMID:23395935 PMID:32151603
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