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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62001
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Muc5ac
Name: mucin 5AC, oligomeric mucus/gel-forming
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Muc5acincreases expressionISOMUC5AC (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of MUC5AC mRNA; Hydrogen Peroxide results in increased expression of MUC5AC proteinPMID:10640773 PMID:33421718
Muc5acmultiple interactionsISOMUC5AC (Homo sapiens)6480464CTD1,3-dimethylthiourea inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]; Dimethyl Sulfoxide inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]; Resveratrol inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC mRNA]; RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC mRNA]; RTKI cpd inhibits the reaction [Hydrogen Peroxide results in increased expression of MUC5AC protein]PMID:10640773 PMID:33421718
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