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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619996
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bche
Name: butyrylcholinesterase
Acc ID: CHEBI:38721
Term: methamidophos
Definition: An organic thiophosphate resulting from the N-deacylation of the proinsecticide acephate.
Chemical ID: MESH:C014655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bchedecreases activityISOBCHE (Homo sapiens)6480464CTDmethamidophos results in decreased activity of BCHE proteinPMID:21673941 PMID:22542756 PMID:26200596
Bchedecreases activityISOBche (Mus musculus)6480464CTDmethamidophos results in decreased activity of BCHE proteinPMID:9890196
Bchemultiple interactionsISOBCHE (Homo sapiens)6480464CTDmethamidophos binds to and results in decreased activity of BCHE protein; Thiosemicarbazones inhibits the reaction [methamidophos results in decreased activity of BCHE protein]PMID:20229498 PMID:22542756
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