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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:9513
Term: thalidomide
Definition: A racemate comprising equimolar amounts of R- and S-thalidomide.
Chemical ID: MESH:D013792
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionEXP 6480464CTDThalidomide results in decreased expression of VEGFA proteinPMID:18291259
Vegfamultiple interactionsEXP 6480464CTD[temozolomide co-treated with Thalidomide] results in decreased expression of VEGFA proteinPMID:16327979
Vegfaaffects expressionISOVEGFA (Homo sapiens)6480464CTDThalidomide affects the expression of VEGFA mRNA; Thalidomide affects the expression of VEGFA proteinPMID:15939924
Vegfaaffects secretionISOVEGFA (Homo sapiens)6480464CTDThalidomide affects the secretion of VEGFA proteinPMID:15939924
Vegfadecreases activityISOVEGFA (Homo sapiens)6480464CTDThalidomide results in decreased activity of VEGFA proteinPMID:17557286
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDThalidomide results in decreased expression of VEGFA mRNA; Thalidomide results in decreased expression of VEGFA proteinPMID:15982930 PMID:21539454 PMID:24154490 PMID:29699374
Vegfadecreases expressionISOVegfa (Mus musculus)6480464CTDThalidomide results in decreased expression of VEGFA mRNAPMID:16313753
Vegfadecreases secretionISOVEGFA (Homo sapiens)6480464CTDThalidomide analog results in decreased secretion of VEGFA proteinPMID:15858615
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDThalidomide results in increased expression of VEGFA proteinPMID:15863203
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD[Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFA mRNA; FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of and results in decreased secretion of VEGFA protein]; Thalidomide results in decreased expression of and results in decreased secretion of VEGFA proteinPMID:29699374 PMID:34520751
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTD[Thalidomide co-treated with Paclitaxel] results in decreased expression of VEGFA mRNAPMID:16313753
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