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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:71418
Term: triamcinolone acetonide
Definition: A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections.
Chemical ID: MESH:D014222
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDTriamcinolone Acetonide results in decreased expression of VEGFA proteinPMID:16029572
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD[Triamcinolone Acetonide binds to NR3C1 protein] which results in decreased secretion of VEGFA protein; Triamcinolone Acetonide inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; Triamcinolone Acetonide inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]; Triamcinolone Acetonide inhibits the reaction [Paraquat results in increased expression of VEGFA mRNA]PMID:15728566 PMID:16029572 PMID:16249516
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