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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionEXP 6480464CTDIndomethacin results in decreased expression of VEGFA mRNA; Indomethacin results in decreased expression of VEGFA mRNA alternative formPMID:16799050 PMID:25972201
Vegfaincreases expressionEXP 6480464CTDIndomethacin results in increased expression of VEGFA mRNAPMID:16184411 PMID:17440234
Vegfamultiple interactionsEXP 6480464CTDIndomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of VEGFA protein]; Indomethacin promotes the reaction [morin inhibits the reaction [Freund's Adjuvant results in increased expression of VEGFA protein]]; morin promotes the reaction [Indomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of VEGFA protein]]PMID:25698669
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDIndomethacin results in decreased expression of VEGFA proteinPMID:15637740
Vegfadecreases expressionISOVegfa (Mus musculus)6480464CTDIndomethacin results in decreased expression of VEGFA proteinPMID:18431645
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTDIndomethacin inhibits the reaction [VEGFA protein results in increased expression of EGR1 mRNA]; Indomethacin inhibits the reaction [VEGFA protein results in increased expression of EGR1 protein]; Indomethacin promotes the reaction [VEGFA protein results in increased expression of ACE protein]PMID:11158990 PMID:11595463
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTD[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of VEGFA mRNA; allylpyrocatechol inhibits the reaction [Indomethacin results in decreased expression of VEGFA protein]PMID:18431645 PMID:33091441
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