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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:32497
Term: thioacetamide
Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
Chemical ID: MESH:D013853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionEXP 6480464CTDThioacetamide results in decreased expression of VEGFA mRNAPMID:34492290
Vegfaincreases expressionEXP 6480464CTDThioacetamide results in increased expression of VEGFA mRNA; Thioacetamide results in increased expression of VEGFA proteinPMID:25051504 PMID:34792689
Vegfaincreases secretionEXP 6480464CTDThioacetamide results in increased secretion of VEGFA proteinPMID:34792689
Vegfamultiple interactionsEXP 6480464CTDFPS-ZM1 inhibits the reaction [S100B protein promotes the reaction [Thioacetamide results in increased expression of and results in increased secretion of VEGFA protein]]; FPS-ZM1 inhibits the reaction [Thioacetamide results in increased expression of and results in increased secretion of VEGFA protein]; S100B protein inhibits the reaction [FPS-ZM1 inhibits the reaction [Thioacetamide results in increased expression of and results in increased secretion of VEGFA protein]]; S100B protein promotes the reaction [Thioacetamide results in increased expression of VEGFA mRNA]; S100B protein promotes the reaction [Thioacetamide results in increased expression of VEGFA protein]; S100B protein promotes the reaction [Thioacetamide results in increased secretion of VEGFA protein]; S100B protein promotes the reaction [VEGFA protein promotes the reaction [Thioacetamide results in increased expression of CYBB protein]]; S100B protein promotes the reaction [VEGFA protein promotes the reaction [Thioacetamide results in increased expression of KDR mRNA]]; S100B protein promotes the reaction [VEGFA protein promotes the reaction [Thioacetamide results in increased expression of NOX1 protein]]; S100B protein promotes the reaction [VEGFA protein promotes the reaction [Thioacetamide results in increased expression of PTGS2 protein]]; S100B protein promotes the reaction [VEGFA protein promotes the reaction [Thioacetamide results in increased expression of TNF mRNA]]; VEGFA protein promotes the reaction [S100B protein promotes the reaction [Thioacetamide results in increased expression of CYBB protein]]; VEGFA protein promotes the reaction [S100B protein promotes the reaction [Thioacetamide results in increased expression of KDR mRNA]]; VEGFA protein promotes the reaction [S100B protein promotes the reaction [Thioacetamide results in increased expression of NOX1 protein]]; VEGFA protein promotes the reaction [S100B protein promotes the reaction [Thioacetamide results in increased expression of PTGS2 protein]]; VEGFA protein promotes the reaction [S100B protein promotes the reaction [Thioacetamide results in increased expression of TNF mRNA]]; VEGFA protein promotes the reaction [Thioacetamide results in increased expression of CYBB protein]; VEGFA protein promotes the reaction [Thioacetamide results in increased expression of NOX1 protein]; VEGFA protein promotes the reaction [Thioacetamide results in increased expression of TNF mRNA]PMID:34792689
Vegfaincreases expressionISOVegfa (Mus musculus)6480464CTDThioacetamide results in increased expression of VEGFA mRNA alternative formPMID:18458672
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTD[Thioacetamide co-treated with Ethanol] results in increased expression of VEGFA proteinPMID:16780996
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