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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfamultiple interactionsEXP 6480464CTDTretinoin inhibits the reaction [sodium arsenite results in decreased expression of VEGFA mRNA]; Tretinoin inhibits the reaction [sodium arsenite results in decreased expression of VEGFA protein]; Tretinoin promotes the reaction [TGFB1 protein results in increased secretion of VEGFA protein]PMID:16598785 PMID:21964460
Vegfadecreases expressionISOVEGFA (Homo sapiens)6480464CTDTretinoin results in decreased expression of VEGFA mRNA; Tretinoin results in decreased expression of VEGFA proteinPMID:16322068 PMID:17261132
Vegfadecreases secretionISOVEGFA (Homo sapiens)6480464CTDTretinoin results in decreased secretion of VEGFA proteinPMID:16116481
Vegfadecreases secretionISOVegfa (Mus musculus)6480464CTDTretinoin results in decreased secretion of VEGFA proteinPMID:16096774
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDTretinoin results in increased expression of VEGFA mRNA; Tretinoin results in increased expression of VEGFA protein; Tretinoin results in increased expression of VEGFA protein polymorphismPMID:16385345 PMID:16386082 PMID:16849523 PMID:17170094
Vegfaincreases expressionISOVegfa (Mus musculus)6480464CTDTretinoin results in increased expression of VEGFA mRNA; Tretinoin results in increased expression of VEGFA proteinPMID:20025956 PMID:26272751
Vegfaincreases secretionISOVEGFA (Homo sapiens)6480464CTDTretinoin results in increased secretion of VEGFA proteinPMID:17170094
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD[Tretinoin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of VEGFA mRNA; [Tretinoin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of VEGFA protein; [Tretinoin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of VEGFA protein modified form; Acetylcysteine inhibits the reaction [[Tretinoin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of VEGFA protein]; Dactinomycin inhibits the reaction [Tretinoin results in increased expression of VEGFA mRNA]; RARA protein promotes the reaction [Tretinoin results in increased expression of VEGFA mRNA]; RARB protein promotes the reaction [Tretinoin results in increased expression of VEGFA mRNA]; RARG protein promotes the reaction [Tretinoin results in increased expression of VEGFA mRNA]PMID:16386082 PMID:17170094 PMID:19910455
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