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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619981
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac6
Name: histone deacetylase 6
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac6decreases activityISOHDAC6 (Homo sapiens)6480464CTDsulforaphane results in decreased activity of HDAC6 proteinPMID:19805354
Hdac6multiple interactionsISOHDAC6 (Homo sapiens)6480464CTDHDAC6 protein inhibits the reaction [sulforaphane results in decreased expression of AR protein]; sulforaphane inhibits the reaction [Estradiol results in increased expression of HDAC6 mRNA]; sulforaphane inhibits the reaction [Genistein results in increased expression of HDAC6 mRNA]PMID:19805354 PMID:30684530
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