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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619980
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac5
Name: histone deacetylase 5
Acc ID: CHEBI:8630
Term: pterostilbene
Definition: A stilbenol that consists of trans-stilbene bearing a hydroxy group at position 4 as well as two methoxy substituents at positions 3' and 5'.
Chemical ID: MESH:C107773
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac5increases phosphorylationISOHDAC5 (Homo sapiens)6480464CTDpterostilbene results in increased phosphorylation of HDAC5 proteinPMID:26443543
Hdac5multiple interactionsISOHDAC5 (Homo sapiens)6480464CTDHDAC5 protein affects the reaction [pterostilbene results in increased expression of SOD2 mRNA]; PRKAA1 protein affects the reaction [pterostilbene results in increased phosphorylation of HDAC5 protein]; pterostilbene inhibits the reaction [HDAC5 protein binds to SOD2 promoter]PMID:26443543
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