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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619976
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac2
Name: histone deacetylase 2
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac2multiple interactionsEXP 6480464CTDVorinostat inhibits the reaction [Sevoflurane results in increased expression of HDAC2 mRNA]; Vorinostat inhibits the reaction [Sevoflurane results in increased expression of HDAC2 protein]PMID:30842370
Hdac2decreases expressionISOHDAC2 (Homo sapiens)6480464CTDvorinostat results in decreased expression of HDAC2 proteinPMID:18850582
Hdac2multiple interactionsISOHDAC2 (Homo sapiens)6480464CTD[vorinostat co-treated with monomethylarsonous acid] results in decreased expression of HDAC2 mRNA; vorinostat binds to and results in decreased activity of HDAC2 proteinPMID:19084294 PMID:23891734
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